Non-melanoma skin cancer (NMSC) treatment has evolved from simple surgical excision and cryotherapy to advanced modalities including Mohs micrographic surgery, targeted therapies, and immunotherapy. Historically, treatments focused on removing visible tumors, but modern approaches emphasize precision medicine and minimizing cosmetic impact. Presently, topical chemotherapies and photodynamic therapy offer non-invasive options. The future promises innovative treatments such as personalized immunotherapy and combination therapies to enhance efficacy and reduce recurrence. Continued research aims to improve outcomes, minimize side effects, and offer tailored treatments based on genetic and molecular profiles