Mycetoma, also known as "Madura foot," is a chronic granulomatous infection primarily caused by fungi or bacteria, leading to tissue swelling, nodules, and sinus formation. Predominantly affecting the lower limbs, it is more prevalent in tropical and subtropical regions. The disease results in significant morbidity and can lead to disability if untreated. Diagnosis involves clinical evaluation, imaging, and microbiological culture. Treatment varies based on the causative agent, with options including antifungal or antibacterial therapy and surgical intervention. Early recognition and management are crucial to prevent complications and improve patient outcomes in endemic areas.