DRESS Syndrome

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe cutaneous drug reaction characterized by fever, lymphadenopathy, hematologic abnormalities, multiorgan involvement, and viral reactivation.1 DRESS incidence varies around 1:1000 to 1:10.000 drug exposures.2 Many culprit drugs associated with DRESS, the culprit drugs may differ according to the region.3–5 Clinical findings generally develop within two months after the intake of medication and most frequently within 2-6 weeks after starting the drug.3,6 The most important for treatment DRESS syndrome is the immediate withdrawal of the causative drug.7 DRESS is a highly morbid and potentially fatal disease, the mortality rate was estimated at 10%.8,9 Patients with DRESS are at risk for long term sequelae and therefore long-term monitoring focused on detecting autoimmune sequelae is recommended for them.1,6