Updates in Management of Epidermolysis Bullosa

Epidermolysis bullosa is a heterogeneouis group of inherited skin fragility disorders caused by mutations in genes encoding structural adhesion proteins at the dermoepidermal junction and in the epidermis. Different forms of EB are characterized by their ultrastructural plane of skin blistering into simplex, junctional, dystrophic and Kindler syndrome.Management of EB is difficult and complex.It requires a multidisciplinary and holitic approach which also includes preventive measures.New curative approaches to treatment have been studied, such as protein replacement, targeted exon deletion, PTC read through, stem cell therapy and natural gene therapy.Each approach has its own challenge and limitation, but provided hope for EB patients.