Spindle Cell Vascular Neoplasm

The challenges and difficulties encountered to diagnose vascular tumours with spindled morphology are due to morphological overlap between different spindle cells vascular tumours of varying malignant potential and behaviour. It may be difficult to distinguish certain benign entities in this category from spindled vascular tumours of intermediate malignancy or even spindled variants of angiosarcoma. Soft tissue tumours with spindle cells can mimics the differential diagnosis particularly for some of the entities that difficult to recognize the vascular nature (non-vasoformative). However, the combination of clinical findings, salient histological features and immunohistochemical markers should allow accurate diagnosis.