Painkillers are important in daily life. Non-steroidal anti-inflammatory drugs (NSAIDs) are powerful pain killers and are widely prescribed by clinicians. Hypersensitivity to NSAIDs is not uncommon due to the high usage rate. Clinicians should familiarize themselves with the various clinical presentations of NSAIDs hypersensitivity. The diagnosis of hypersensitivity to NSAIDs is very important as the patient must know the NSAIDs he/she can tolerate, apart from knowing which one to avoid. The challenge test is, therefore, the most essential diagnostic tool.