Update on Itch Mechanism in Atopic Dermatitis

Itching is one of the major diagnostic criteria of atopic dermatitis and one of its most troublesome symptoms.Chronic itch in inflammatory skin diseases, such as atopic dermatitis, markedly diminishes the quality of life of affected individuals.
Optimal control of itching can go a long way towards controlling the eczema itself; it can also make a major contribution to the physical and emotional improvementof the patient andcaregivers .
Comprehensive progress has been made in understanding itch signaling and associated mediators in the skin, dorsal root ganglia, spinal cord, and central nervous system, which may amplify or suppress atopic itch. Itch related to Atopic dermatitis is beyond histamine . Other cytokines include IL 4 , IL 13 , IL 31 and TSLP.
Exploring itch pathways and mechanisms may lead to novel therapeutic approaches for atopic itch.